Title: Biological in vitro investigation of PBT in industrial and environmental samples

Auteur(s): Schramm K-W ; Rehmann K ;  ; 

Year: 2000

Journal: Organohalogen Compounds

Subject(s):  ; 

Summary: The (eco-)toxicity of products and emissions is of interest for their environmental and human impact assessment on regional and global levels. Although in the past the analytical techniques improved rapidly, there is a huge gap in the quantitative evaluation of the risk of complex mixtures of compounds. Therefore, a complemental bioanalytical strategy has been proposed and developed (Schramm et al. 1999) to investigate any sample (eco-)toxicologically by focusing on the most important effects which can be obtained from current in vitro testing. The main goal is the testing of compounds which have a low water solubility and vapour pressure. These persistent bioaccumulating toxicants (PBT) accumulate in biological systems according to their lipophilicity and they exhibit long-term or chronic toxicological properties. Tools for their quantitative investigation (exposure and toxicology) are poorly developed. Therefore, a novel test strategy has been developed and applied to control present and future emissions of end of pipe technologies as well as waste and material streams using the following target specific (PBT) approach.