Title: Combinatorial bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, fee/food, humans/wildlife and the environment

Auteur(s): Behnisch PA ; Hosoe K ; Sakai S ;  ; 

Year: 2001

Journal: Inviron Intern

Subject(s): bioassay ; Biomarker ; biomonitoring ; dioxin ; dioxin toxicity equivalent quotient (TEQ) ; dioxin-like compounds ; dioxins ; relative responses (RPEs) ; waste recycling ; analysis ; environment ; furans ; polychlorinated ; Ah receptor ;  ; 

Summary: The present review describes international activities using bioassays/biomarkers in combination with chemical analysis to measure the effects of dioxin and dioxin-like compounds (DLCs) in the environment. The above authors reviewed already the state-of-art bioanalytical detection methods (BDMs) for dioxins and DLCs [Environ Int (2001)]. The aim of this study will be to review applications of these bioassays/biomarkers to evaluate potential dioxins and DLCs. The present literature study lists relative potencies (REPs) of polyhalogenated dibenzo-p-dioxins and -furans (PXDD/Fs; X = Cl, Br, F), their thio analogues polychlorinated dibenzothiophenes (PCDTs) and thianthrens (PCTAs), polyhalogenated biphenyls (PXBs), polychlorinated naphthalenes (PCNs) and other Ah receptor agonists measured by several biodetectors (Tier 3 screening). The authors will discuss some examples of the applications of some of these biodetectors in biomonitoring programmes and recently occurred dioxin crisis in feed/food. The diagnosis of the biopotency of these pollutants in technical processes like thermally treated waste, waste water treatment, landfill leachate treatment, commercial PCB-mixtures, the release into the environment (soil, air and water) and the final intake into wildlife and humans will be reviewed.