Title: Results of the first International Interlaboratory DR CALUX® by BDS comparison study for food and feed (BICS 2005)

Auteur(s): Besselink HT ; Felzel E ; Jonas A ; Brouwer A ;  ; 

Year: 2006

Journal: Organohalogen Compounds

Subject(s): CALUX ; feed ; food ; interlaboratory comparison ; limit-values ; dioxins ; dioxin ; bioassay ; monitoring ; PCBs ; PCB ; DR CALUX ;  ; 

Summary: Food and feed safety is a high priority issue for the food and feed sector as it directly impacts on human and animal health. Stringent EU limit values are in force for dioxins in food- and feedingstuffs1,2 for animal and public health protection. The use of the DR CALUX® by BDS bioassay for monitoring dioxins in food and feed allows the (pre)-selection of samples suspected of being contaminated above limit values with dioxins. To permit bioassays to be used for screening of food- and feedingstuffs, the EU has laid down general requirements for the determination of dioxins and dioxin-like PCBs in food- and feedingstuffs and specific requirements for cell-based bioassays3,4. To ensure the reliability and performance of the DR CALUX by BDS bioassay for monitoring food and feedingstuffs, an interlaboratory comparison study (ringtest) is mandatory.In the present paper, the results of the first international DR CALUX® interlaboratory comparison study (BICS 2005) organized by BioDetection Systems BV (BDS) are described. A total of 21 laboratories world wide using the DR CALUX® bioassay in house participated in the BICS-2005 study. The protocol of the BICS-2005 study was divided into three phases. The complexity of analyses increased with the phases.