Date: 2008-01-24Source: BioDetection SystemsLaunch of BDS’ newsletter
Dear reader,
We are happy to announce the first newsletter of BioDetection Systems offering you an overview of news on ‘biodetectors’. In our newsletter we will inform you about the state-of-the-art of innovative biological detection systems in the analytical world, including new applications and validation of existing methods. With increased interest and use of these assays in food-, environmental-, pharmaceutical-, public health and clinical analysis we will have ample material for our issues that so far are planned to appear three to four times a year. Most news items will be linked to BDS’ homepage, which we hope will become an important source of information on these innovative technologies. Please do not hesitate to contact us with questions, comments, ideas and news items. We wish you pleasant reading.
With best regards,
Peter Behnisch and Bart van der Burg
This letter contains the following topics:
• International conference on biodetectors
• New business cooperations
• Meet BDS
• New products
• Selection of recent publications on CALUX® and other “Biodetectors”
• Upcoming events
International conference on biodetectors
At August 15, preceding the Dioxin 2008 conference in Birmingham, England, BDS will organise the 3rd International BioDetectors Conference in Amsterdam. This annually recurring event has attracted in the last two years more than 70 participants from all over the world. In contrast to previous years, the 3rd conference will be one day only with a morning program of presentations by well-known experts in the field of BioDetectors for environmental, feed/food, human biomonitoring, and doping. In the afternoon there will be a possibility to visit BDS’ laboratories and demonstrations of a range of CALUX technologies for different applications will be given. In Spring 2008 BDS will launch a call for abstracts and information about how to register for the 2008-conference.
New business cooperations
BDS
is happy to announce the establishment of various new global partners to be
able to meet the increasing demands and to further improve local services. A
listing of all BDS’ global partners can be viewed at our homepage. click
here for list
Meet
BDS
There will be various possibilities to meet BDS personnel early
in 2008. Among that there will be seminars in various countries. If you are
interested in attending one of these seminars, please refer to the contact details
given in the upcoming events section. If you are interested in more direct information
by BDS, please contact BDS or one of our global partners.
New products
Reference
materials
Reference materials have been generated for food and feed
analysed for dioxins and dioxin-like PCBs. The materials have been analysed
by 21 DR CALUX laboratories and 2 HRGC/HRMS laboratories. Prices are: one for
240 €; three for 590 €. A complete listing of products can be viewed at our
homepage. click
here for list
Panel of CALUX cells
Through our continuous R&D
activities we now have expanded the panel of CALUX cell lines extensively. These
assays can be used for a wide variety of applications and in coming issues of
BioDetectors we will be presenting application notes to give you a flavour of
what these cell lines could mean for your work. The extension of this highly
standardised panel of reporter cell lines will be a continuing activity in the
coming years, and already several new assays are currently being developed (as
indicated in white). Please contact us for further information on any of these
assays. We would be happy to discuss your specific needs.
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CALUX line |
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target |
receptor/ pathway |
Typical ligands |
Examples for area of application |
| DR | endogenous | Dioxins, PAHs, PCBs | food&feed,
environment, epidemiology |
| ER | endogenous | Estrogens, EDCs | all*, cancer, menopause, repro |
| ERalpha | introduced | Estrogens, EDCs | all*, cancer, menopause, repro |
| ERbeta | introduced | Estrogens, EDCs | all*, cancer, menopause |
| AR | introduced | Androgens, EDCs | all*, cancer, doping, repro |
| PR | introduced | Progestins | all*,
repro |
| GR | introduced | Glucocorticoids | all*, inflammatory, diseases |
| TR | introduced | Thyroid hormones | all*, metabolism, brain development |
| TRbeta | introduced | Thyroid hormones | all*, metabolism, brain development |
| RAR | endogenous | Retinoids | all*, teratogenicity |
| NFkappaB | endogenous | Cytokines Toxins |
clinical, pharma, inflammatory diseases |
| PXR | forthcoming |
|
metabolic syndrome |
| PPAR | forthcoming |
|
metabolic syndrome |
all*: Food and feed, environment, epidemiology, clinical,
pharma, reproduction
Selection of recent publications on
CALUX®
and other “Biodetectors”
Hui LL, Hedley AJ, Nelson EA, Malisch
R, Wong TW, Cowling BJ (2007) Agreement between breast milk dioxin levels by
CALUX bioassay and chemical analysis in a population survey in Hong Kong. Chemosphere
69,1287-94.
DR CALUX® bioassay analysis and gas chromatography/mass
spectrometry (GC/MS) showed comparable results in paired breast milk samples.
Bogers, R., De Vries-Buitenweg, S., Geuijen, I., De Roode, D., Kuiper,
R., Van der Linden, S., Puiker, L., Murk, A.J., Van der Burg, B. & Legler,
J. (2007). An in vitro/in vivo screening assay as a sensitive tool to assess
endocrine disruptive activity in surface water. Environment International 33,
292-301.
This study on estrogenic activity in river water showed that
the results obtained by the ER CALUX assay are consistent with that of an in
vivo fish study using the same water samples.
Sonneveld E, Jonas A, Meijer
OC, Brouwer A, Van der Burg B. (2007). Glucocorticoid Enhanced Expression of
Dioxin Target Genes through Regulation of the Rat Aryl Hydrocarbon Receptor.
Toxicol Sci. 99, 455-469.
This study determines the mechanism of interference
of glucocorticoids in the DR CALUX assay. This information is used to guarantee
the selectivity of the assay using new matrices, such as clinical material.
BioDetectors
conference report
BioDetectors 2007, hosted by BDS, Amsterdam, The Netherlands
More than 20 speakers and poster presenters contributed to this event with
several presentations which can be download from the BDS website.
Upcoming events
BDS seminars
Australia
February 5-7, Peter
Behnisch (In cooperation with Mr. Udo Rupprecht, Lasersan Australia Pty Ltd)
“BioDetectors for environmental, feed/food, clinical and Sport Doping Bioanalysis”
Location: University of Queensland, Brisbane (Feb 5), in Adelaide (Feb
6) and at the National Measurement Institute (NMI) in Sydney (Feb 7). Please
contact BioDetection Systems or Lasersan for more details.
Thailand
February
11, Peter Behnisch (In cooperation with Sithiporn Associates)
“BioDetectors
for environmental, feed/food, clinical and Sport Doping Bioanalysis”
Location:
Sithiporn Associates in Bangkok on February 11. Please contact BioDetection
Systems or Sithiporn Associates for more details.
Germany
February 14, Peter Behnisch
„Measurement of environmental
pollutants, hormones and anabolic steroids by using stably transfected cells
(e.g. DR CALUX Method)”
Location: Radisson SAS Hotel Leipzig (9:00, entrance
8:30), Augustusplatz 5–6, Leipzig. +49 (0)341- 2146 845. E-Mail: robert.haenzel@radissonsas.com
Reservations before February 7.
February 15, Peter Behnisch
“Effect
based Bioanalysis of POPs and Endocrine Disrupters”
Location: German
Environmental Bundesamt 10:30 in the Hörsaal of the Umweltbundesamt, Corrensplatz
1, 14195 Berlin.
Netherlands
March 13, Bart van der Burg
“De
toepassing van toxiciteitstesten voor het wateronderzoek, de nieuwste trends
en methoden” (in Dutch). Symposium: “Nieuwe ontwikkelingen in de analyse van
organische verbindingen in water”.
Location: Kiwa Water Research, Nieuwegein (NL). Please contact Kiwa Water
Research (gemma.van.beusekom@kiwa.nl) for more details on this symposium.
Spain
May
7, Bart van der Burg
“Mammalian Cell-based Detection Methods to Detect Toxic
Substances” Conference: “Advances in biodefense technology”
Location: Palau
De Congressos De Catalunya, Barcelona, Spain. For more details, please contact
Select Biosciences (enquiries@selectbiosciences.com)
International
conferences
|
February, 19-20 |
ADMET in Stockholm. |
|
February, 25-29 |
Manfred Donike Workshop; 25th Cologne Workshop on Doping Analysis. |
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April , 13-18 |
Several sediment sessions at the European Geosciences Union annual
symposium in Vienna, Austria. |
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March , 12-15 |
DGAUM (Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin)
in Hamburg. |
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May , 7-8 |
Advances in biodefense technology in Barcelona http://www.selectbiosciences.com/conferences |
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May, 27-29 |
5th International SedNet Conference, Oslo, Norway. Urban Sediment
Management and Port Redevelopment / Sediment in River Basin Management
Plans. Call for Abstracts: |
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July, 10-12 |
International Symposium on Sediment Management, Lille – France.
More information at |
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August, 15 |
3rd BioDetectors Conference 2008. |
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August, 16-22 |
27th DIOXIN Conference 2008 in Birmingham, England. |
Disclaimer: BDS compiles this newsletter
with the greatest care. BDS, however, does not necessarily support contents
or views expressed in this newsletter or that of the linked sites and documents,
nor guaranties accuracy of the information provided. It accepts no liability
for consequent losses or damages due to the contents of this letter and linked
information.
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