Date: 2010-04-14Source: BDS
Panel of CALUX assays
Through our
continuous R&D activities we now have expanded the panel of CALUX®
cell lines extensively. The areas of
application of these assays are divers and include environmental, food and
feed, clinical, pharmaceutical, sport doping, occupational health and
toxicity monitoring of chemicals. Various of these applications have been
described in our new brochures (click
here for the BDS CALUX brochure and here
for the R&D Partnering brochure). The extension of this highly standardised panel of
reporter cell lines will be a continuing activity in the coming years, and
already several new assays are currently being developed (examples indicated in
white). Please contact us for further information on any of these assays. Our
R&D department can rapidly generate new assays, also custom-made. We would
be happy to discuss your specific needs.
|
Name |
Examples applications |
Ligands |
|
DR CALUX |
Clinical, food, environment, reproduction, cancer |
Dioxins and dioxin-like chemicals |
|
PAH CALUX |
Clinical, food, environment, reproduction, cancer |
Carcinogenic PAHs |
|
ER CALUX |
Clinical, food, pharma, environment, reproduction, cancer |
Estrogens, EDCs |
|
ERalpha CALUX |
Clinical, food, pharma, environment, reproduction, cancer |
Estrogens, EDCs |
|
ERbeta CALUX |
Clinical, food, pharma, environment, reproduction, cancer |
(Phyto)Estrogens, EDCs |
|
AR CALUX |
Clinical, food, pharma, environment, reproduction, cancer, doping |
Androgens, EDCs |
|
PR CALUX |
Clinical, food, pharma, environment, reproduction, cancer |
Progestins, EDCs |
|
GR CALUX |
Clinical, food, pharma, environment, doping, inflammation |
Glucocorticoids, EDCs |
|
TR CALUX |
Clinical, food, pharma, environment, energy metabolism |
Thyroid hormones, EDCs |
|
RAR CALUX |
Clinical, food, pharma, reproduction, cancer, teratogenicity, cosmetics |
Retinoids |
|
PPAR CALUX |
Clinical, food, pharma, environment, cancer, metabolic syndrome |
Wide range |
|
kappaB CALUX |
Clinical, food, pharma, environment, inflammation, stress |
Pro-inflammatory cytokines |
|
P21 CALUX |
Clinical, food, pharma, environment, cell/DNA damage |
Genotoxic agens |
|
Cytox CALUX |
Environment, food, pharma, cytotoxicity, specificity control |
Cytotoxic agents |
|
Nrf2 CALUX |
Clinical, food, pharma, environment, cancer, cell protection |
Electrophiles, ox stress |
|
P53 CALUX |
Clinical, food, pharma, environment, cell/DNA damage |
Cytotoxic agents |
|
AP1 CALUX |
Clinical, food, pharma, environment, reproduction, cancer |
Carcinogens, UV |
|
Etc. |
|
|
|
 |
|