Publications

Aarts, J.M.M.J.G., P.H. Cenijn, B.M.G. Blankvoort, et al. (1996).Application of the chemical= activated luciferase expression (CALUX) bioassays for quantification of dioxin-like compounds in small samples of human milk and blood plasma. Organohalogen Compounds 27, 285-90.

Aarts, J.M.M.J.G., M.S. Denison, M.A. Cox, et al. (1995). Species-specific antagonism of Ah receptor action by 2,2?,5,5?-tetrachloro- and 2,2?,3,3?,4,4?-hexachlorobiphenyl. European Journal of Pharmacology, Environmental Toxicology and Pharmacology Section 293, 463-74.

Aarts, J.M.M.J.G., M.S. Denison, L.H.J. de Haan, et al. (1993). Ah-receptor mediated luciferase expression: a tool for monitoring dioxin-like toxicity. Organohalogen Compounds, 13, 361-4.

Aarts, J.M.M.J.G., M.S. Denison, L.H.J. de Haan, et al. (1993). Antagonistic effects of diortho PCBs (PCB 52 and 128) on Ah receptor-mediated induction of luciferase activity by 3,3’,4,4’-tetrachlorobiphenyl (PCB 77) in mouse Hepa-1c1c7 cells. Organohalogen Compounds, 14, 69-72.

Adams, C., M.C. Lans, E. Klasson-Wehler, et al. (1990). Hepatic thyroid hormone 5’-deiodinase, another target protein for monohydroxy metabolites of 3,3’,4,4’-tetrachlorobiphenyl. In: 10th International Meeting on Dioxins, 1990 Bayreuth, W-Germany, vol. 1, 51-4, Ecoinforma Press, Bayreuth.

Ahlborg, U.G., G.C. Becking, L.S. Birnbaum, et al. (1994). Toxic equivalency factors for dioxin-like PCBs. Report on a WHO-ECEH and IPCS consultation, December 1993, Chemosphere 28, 1049.

Alink, G.M., A. Brouwer, and G.A.H. Heussen (1994). Effects of outdoor and indoor airborne particulate matter on thyroid hormone and vitamin A metabolism, Toxicol. Lett.,72, 73-81.

Almeida, M.R., A.M. Damas, M.C. Lans, et al. (1997). Thyroxine binding to transthyretin Met 119: comparative studies of different heterozygotic carriers and structural analysis. Endocrine. 6 (3) 309-15.

Almeida, M.R., M.C. Lans, A. Brouwer, et al. (1994). Thyroxine binding to transthyretin variants, 3rd European Congress of Endocrinology, Amsterdam.

Beetstra, J.B., J.G.M. van Engelen, P. Karels, et al. (1991). Different enzymes for the glucuronida­tion of T4 and T3 in rat liver. In: Proceedings of 10th Thyroid Congress, Den Haag.

Beetstra, J.B., J.G.M. van Engelen, P. Karels, et al. (1991). Thyroxine and 3,3’,5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases. Endocrinol. 128 (2), 741-6.

Behnisch, P.A., Hosoe, K., Brouwer, A. & Sakai, S. (2002). Screening of dioxin-like toxicity equivalents for various matrices with wildtype and recombinant rat hepatoma H4IIE cells. Toxicological Sciences, 69(1), 125-30.

Berkers, J.A.M., G.A.M. Hassing, A. Brouwer, et al. (1993). Antagonistic effects of retinoic acid on the 2,3,7,8-tetrachlorodibenzo-p-dioxin induced differentiation of in vitro cultured human kerati­nocytes. Organohalogen Compounds, 13, 325-8.

Berkers, J.A.M., G.A.M. Hassing, A. Brouwer, et al. (1994). Effects of retinoic acid on the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced differentiation of in vitro cultured human keratinocytes, Toxic. in vitro, 8 (4), 605-8.

Berkers, J.A.M., I. Hasing, B. Spenkelink, et al. (1995). Interactive effects of 2,3,7,8-tetrachlorodin­benzo-p-dioxin and retinoids on proliferation and differentiation in cultured human keratinocytes: quantification of cross-linked envelope formation. Arch. Toxicol. 69, 368-78.

Besselink, H., Jonas, A., Pijnappels, M., Swinkels, A. & Brouwer, A. (2004). Validation of extraction, clean-up and D Calux® bioanalysis.part i: Feedingstuff. Organohalogen Compounds, 66, 677-681.

Besselink, H., Jonas, A., Pijnappels, M., Swinkels, A. & Brouwer, A. (2004). Validation of extraction, clean-up And Dr Calux® bioanalysis.Part II: Foodstuff. Organohalogen Compounds, 66, 682-686.

Besselink, H.T., Schipper, C., Klamer, H., Leonards, P., Verhaar, H., Felzel, E.C., Murk, A.J., Thain, J., Hosoe, K., Schoeters, G., Legler, J. & Brouwer, A. (2004). Intra- and interlaboratory calibration of the DR-Calux bioassay for the analysis of dioxins and dioxin-like chemicals in sediments. Environmental Toxicology and Chemistry, 23(12), 2781-2789.

Besselink, H., Jonas, A., Pijnappels, M., Swinkels, A., Fjellanger, K. & Brouwer, A. (2003). Comparison of DR Calux® and HRGCMS-derived TEQ’s: introduction of conversion factors. Organohalogen Compounds, 60, pp 203-206.

Besselink, H.T., A. Brouwer, and A.D. Vethaak (1996). Effects on retinoid homeostasis in the flounder (Platichthys flesus) following chronic exposure to contaminated harbour dredge spoil from Rotterdam harbour Organohalogen Compounds 29, 18-21.

Besselink, H.T., S. van Beusekom, and A. Brouwer (1993). Low hepatic ethyoxyresorufin-o-deethy­lase (EROD) induction with no detectable cytosolic Ah-receptor levels in Flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50. Organohalogen Compounds, 14, 141-4.

Besselink, H.T., S. van Beusekom, E. Roex, et al. (1996). Low hepatic 7-ethoxyresorufin-o-deethy­lase (EROD) activity and minor alterations in retinoid and thyroid hormone levels in flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50. Environmental Pollution, 92, 267-74.

Besselink, H.T., E. van Santen, W. Vorstman, et al. (1997). High induction of cytochrome P4501A activity without changes in retinoid and thyroid hormone levels in flounder (Platychtys Flesus) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environm. Toxicol. & Chem. 16 (4), 816-23.

Bosveld, A.T.C., J. Gradener, A.J. Murk, et al. (1994). Effects of PCBs, PCDDs and PCDFs in common tern (Sterna hirundo) breeding in estuarine and coastal colonies in the Netherlands and Belgium, J. Environ. Toxicol. Chem., 14, 99-115.

Bovee, T.H.F., L.A.P. Hoogenboom, W.A. Traag, et al. (1996). Biological screening of Ah receptor agonist activity in butter fat and coconut oil by means ofchemical-activated luciferase expression in a genetically enginered cell line (CALUX). Organohalogen Compounds 27, 303-8.

Brouwer, A., E. Sopnneveld, S. Sterk, R. Stephanuy & B. van der Burg (2006). Development of CALUX bioassay-based systems as instrument to detect hormones and contaminants. J. Veterinary Pharmacol. & Therapeutics 29(51): 55 (extended abstract).

Brouwer, A., Sonneveld, E., Botschuijver, S., Besselink, H. & Burg, B. Van Der (2004). A low volume method for the analysis of dioxins and dioxin-like compounds in serum and whole blood using BDS' Dr Calux® Bioassay. Organohalogen Compounds, 66, 687-690.

Brouwer, A., Botschuiver, S., Veerhoek, D., Besselink, H.T., Hamm, S, Traag, W., & Zimpfer, M. (2005). Observation of an extremely high dioxin level in a human serum sample from ukraine by Dr Calux®, which was confirmed to be 2,3,7,8-tetrachlorodibenzo-p-dioxin by GC-HRMS. Organohalogen Compounds, 67, 1705-1708.

Brouwer, A. (2001). Onvoldoende Bekende en Onderkende Gezondheids- en Veiligheidsproblemen. Essay ten behoeve van NMP4.

Brouwer, A. (1989). Inhibition of thyroid hormone transport in plasma of rats by polychlorinated biphenyls Arch. Toxicol. Suppl. 13, 440-5

Brouwer, A. (1987). Interference of 3,4,3’,4’-tetrachlorobiphenyl in vitamin A (retinoids) metabo­lism; possible implications for toxicity and carcinogenicity of polyhalogenated aromatic hydro­carbons. Thesis Leiden, Kripps Repro Meppel.

Brouwer, A. (1989). Polyhalogeenaromaten en het metabolisme van vitamine A (retinoiden) Voeding 50 (6/7), 162-7.

Brouwer, A. (1991). Role of biotransformation in PCB-induced alterations in vitamin A and thyroid hormone metabolism in laboratory and wildlife species. Biochem. Soc. Transact. 19, 731-7.

Brouwer, A., U.G. Ahlborg, M. van den Berg, et al. (1995). Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants. Eur. J. Pharmacol.[Environm. Toxicol. & Pharmacol. section], 293, 1-40.

Brouwer, A., W.S. Blaner, A. Kukler, et al. (1988). Study on the mechanism of interference of 3,4,3’,4’-tetrachlorobiphenyl with the plasma retinol-binding proteins in rodents. Chem-Biol. Interact., 68, 203-17.

Brouwer, A., H. Burger, and G. Wagemaker (1980). Purification and properties of colony stimula­ting factor (CSF) isolated from pregnant mouse uteri. Ann Rep. TNO, 39-42.

Brouwer, A., and S.K. Durham (1988). Serum and hepatic retinoid reduction and morphologic changes induced by 3,4,3’,4’-tetrachlorobiphenyl (TCB) in the rat liver. Ann. Meeting Soc. Toxicol. 881.

Brouwer, A., H.Hakansson, A. Kukler, et al. (1989). Marked alterations in retinoid homeostasis of Sprague-Dawley rats induced by a single i.p. dose of 10 ug/kg of 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicol. 58, 267-83.

Brouwer, A., E. Klasson-Wehler, M. Bokdam, et al. (1990). Competitive inhibition of thyroid hor­mone binding to transthyretin in vivo and in vitro by monohydroxy-metabolites of 3,4,3’,4’-tetra­chlorobiphenyl. Chemosphere, 20(7-9), 1257-62.

Brouwer, A., A. Kukler, and K.J. van den Berg (1988). Alterations in retinoid concentrations in several extrahepatic organs of rats by 3,4,3’,4’-tetrachlorobiphenyl. Toxicol. 50, 317-30.

Brouwer, A., A. Kukler, and K.J. van den Berg (1984). Induced metabolism of retinol in livers of C57BL/Rij mice after exposure to polychlorinated biphenyls. Ann. Rep. TNO, 47-9.

Brouwer, A., A. Kukler, and K.J. van den Berg (1985). Interaction of 3,4,3’,4’-tetrachlorobiphenyl with transthyretin, a plasma protein involved in vitamin A (retinol) and thyroid hormone transport. Ann. Rep. TNO, 43-6.

Brouwer, A., A. Kukler, and K.J. van den Berg (1986). Potential retinoid deficiencies in several tissues of rats following exposure to 3,4,3’,4’-tetrachlorobiphenyl. Ann. Rep. TNO, 45-8.

Brouwer, A., A. Kukler, and K.J. van den Berg (1982). Reduced liver storage and plasma transport of retinoids in mice after exposure to 3,4,3­‘,4’-tetrachlorobiphenyl. Ann. Rep.TNO, 65-8.

Brouwer, A., M.C. Lans, J.H.L. de Haan, et al. (1994). Formation and toxicological aspects of phenolic metabolites of polychlorobiphenyls (PCBs) and related compounds, Organohalogen Compounds, 20, 465-9.

Brouwer, A., and D.C. Morse (1991). Interference of polychlorinated biphenyls in thyroid hormone metabolism: possible neurotoxic consequences in fetal and neonatal rats.11th International Sym­posium on Chlorinated Dioxins and Related Compounds, pp. 56.

Brouwer, A., D.C. Morse, M.C. Lans, et al. (1998). Interactions of persistent environmental organo­halogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health. Toxicol. & Industr. Health vol 14 (1/2), 59-84.

Brouwer, A., A.J. Murk, and J.H. Koeman (1990). Biochemical and physiological approaches in ecotoxicology. Fundam. Ecology vol 4, 275-81.

Brouwer, A., and K.J. van den Berg (1986). Binding of a metabolite of 3,4,3’,4’-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein com­plex carrying both retinol and thyroxin. Toxicol. Appl. Pharmacol. 85, 301-12.

Brouwer, A., and K.J. van den Berg (1984). Early and differential decrease in natural retinoid levels in C57BL/Rij and DBA/2 mice by 3,4,3’,4’-tetrachlorobiphenyl. Toxicol. Appl. Pharmacol. 73, 204-9.

Brouwer, A., and K.J. van den Berg (1983). Early decrease in natural retinoid levels in mice after ex­posure to low doses of polychlorinated biphenyls. Chemosphere 12, 555-7.

Brouwer, A., and K.J. van den Berg (1983). Marked differences in the kinetics of serum retinol re­duction by PCBs in C57BL/Rij and DBA/2 mice. Ann. Rep. TNO, 39-42.

Brouwer, A., K.J. van den Berg, W.S. Blaner, et al. (1986). Transthyretin (prealbumin) binding of PCBs. A model for the mechanism of nterference with vitamin A and thyroid hormone metabo­lism. Chemosphere, 15, (9-12) 1699-706.

Brouwer, A., K.J. van den Berg, and A. Kukler (1984) .Induction of hypovitaminosis A in rodents, a possible mechanism of tumour promotion by polychlorinated biphenyls. Dermatologica 169, 226-7.

Brouwer, A., K.J. van den Berg ,and A. Kukler (1985). Time and dose responses of the reduction in retinoid levels in C57BL/Rij and DBA/2 mice induced by 3,4,3’,4’-tetrachlorobiphenyl. Toxicol. Appl. Pharmacol. 78, 180-9.

Buitenhuis, C.J.K., Cenijn, P.H., Velzen, M.J.M. van, Lilienthal H., Malmberg, T., Berman, A, Gutleb, A.C., Legler J., & Brouwer, A. (2006). Prenatal exposure of rats to hydroxylated PCBs and some brominated frame retardants. IVM Working Paper 06/1. Instituut voor Milieuvraagstukken, Amsterdam.

Coenen, T.M.M., A. Brouwer, I.C. Enninga, et al. (1992). Subchronic toxicity and reproduction effects of Tri-n-butyltinoxide in Japanese Quail. Arch. Environm. Contam. Toxicol. 23, 457-63.

Coenraads, P-J., A. Brouwer, K. Olie, et al. (1994). Chloracne: some recent issues, Dermatol. Clinics, 12 (3), 569-76.

Craane, B.L.H.J., A. Brouwer, S. van Mourik, et al. (1990). A comparative laboratory study with Cormorants (Phalacrocorax carbo) from two Dutch colonies with different degree in Contamina­tion. In: 10th International Meeting on Dioxins, 1990, Bayreuth, W-Germany, vol.4, 207-10, Ecoinforma Press, Bayreuth.

Darnerud, P.O., D.C. Morse, E. Klasson-Wehler, et al. (1996). Binding of a 3,3’,4,4’-tetrachlorobi­phenyl (CB-77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice. Toxicology, 106, 105-14.

De Guise, Sylvain et al. (2001).Consensus Statement – Atlantic Coase Contaminants Workshop 2000. Environmental Health Perspectives (accepted for publication scheduled for print in December, 2001).

De Haan, L.H.J., T.A. Bos, J.M.M.J.G. Aarts, et al. (1993). Inhibition of intercellular communica­tion by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): possible role of the Ah-receptor. Organo­halogen Compounds, 13, 157-60.

De Haan, L.H.J., S. Halfwerk, S.E.L. Hovens, et al. (1996). Inhibition of intercellular communica­tion and induction of ethoxyresorufin-o-deethylase activity by polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans in Mouse Hepa1c1c7 cells. Env. Toxicol. & Pharmacol. 1, 27-37.

De Haan, L.H.J., J.W.F.A. Simons, A.T. Bos, et al. (1994). Inhibition of intercellular communica­tion by 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like PCBs in mouse hepatoma cells (hepa1c1c7): involvement of the Ah-receptor. Toxicol. Appl. Pharmacol., 129, 283-93.

De Haan, L.H.J., L. van Dijk, and A. Brouwer (1994). Effects of hydroxylated PCB metabolites on the Gap-Junctional Intercellular Communication between mouse Hepa1c1c7 cells, Organoha­logen Compounds, 20, 491-5.

De Leeuw, A.M., A. Brouwer, K.J. van den Berg, et al. (1983). Cellular distribution of vitamin A in rat liver studied in isolated fat-storing and other liver cells. Proc. Nutr. Soc. 42 (no 1), 8A.

Den Besten, C., M.H.J. Bennik, I. Bruggeman, et al. (1993). The role of oxidative metabolism in hexachlorobenzene-induced Porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study. Toxicol. Appl. Pharmacol., 119, 181-94.

Den Besten, C., A. Brouwer, I.C.M.C. Rietjens, et al. (1994). Biotransformation and toxicity of halogenated benzenes. Human and Experimental Toxicology, 13 (12), 866-75.

Denison, M.S., M.H. El-Fouly, J.M.M.J.G. Aarts, et al. (1993). Production of novel recombinant cell line bioassay systems for detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Organohalogen Compounds, 13, 365-8.

Denison, M.S., P.M. Garrison, J.M.M.J.G. Aarts, et al. (1995). Species-specific differences in Ah receptor ligand binding and transcriptional activation: implications for bioassays for the detection of dioxin-like chemicals. Organohalogen Compounds 23, 225-9.

Denison, M.S., W.J. Rogers, M. Fair, et al. (1996). Application of CALUX bioassay system for the detection of dioxin-like chemicals (Ah receptor ligands) in whole serum samples and in extracts from commercial and consumer products. Organohalogen Compounds, 27, 290-4.

De Swart, R.L., P.S. Ross, H.H. Timmerman, et al. (1995). Short term fasting does not aggravate immunosuppression in harbour seals (Phoca vitulina) with high body burdens of organochlorines. Chemosphere 31 (10), 4289-306.

Dickerson, R.L., A. Brouwer, L.E. Gray, et al. (1998). In: Principles and processes for evaluating endocrine disruption: Chapter 4: dose-response relationships, SETAC Press, 69-96.

Durham, S.K., and A. Brouwer (1989). 3,4,3’,4’-tetrachlorobiphenyl-induced effects in the rat liver. I. Serum and hepatic retinoid reduction and morphologic changes. Toxicol. Pathol. 17 (3), 536-44.

Durham, S.K., and A. Brouwer (1990). 3,4,3’,4’-tetrachlorobiphenyl-induced effects in the rat liver. II. Electron microscopic autoradiographic localization of 3H-TCB. Toxicol Pathol. 17(4), 782-8.

Durham, S.K.. and A. Brouwer (1990). 3,4,3’,4’-tetrachlorobiphenyl distribution and induced effects in the rat adrenal gland: localization in the zona fasciculata. Lab. Invest. 62(2), 232-9.

Garrison, P.A., K. Tullis, J.M.M.J.G. Aarts, et al. (1996). Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fund. & Appl. Toxicol., 30, 194-03.

Ghosh, M., I. Meerts, A. Cook, A. Bergman, A. Brouwer and L.N. Johnson (2000) Structure of human transthyretin complexed with bromophenols: a new mode of binding. Acta Crystallographica Section D-Biological Crystallography, 56: 1085-1095.

Hamers, T., Kamstra, J.H., Sonneveld, E., Murk, A.J., Zegers, B.N., Boon, J.P. & Brouwer, A. (2004) In vitro screening of the endocrine disrupting potency of brominated flame retardants and their metabolites. Organohalogen Compounds, 66, 2974-2978.

Hamers, T, Kamstra, JH, Sonneveld, E, Murk, AJ, Kester, MHA, Andersson, PL, Legler, J and Brouwer, A. (2006) .In vitro profiling of the endocrine disrupting potency of brominated flame retardants. Toxicological Science, 92, 157-173.

Hamers, T.H.M., Kamstra, J.H., Sonneveld, E., Brouwer, A., Murk, A.J., Andersoon, P.L., Boon, J.P., Ven, L.T.M. van der, Hopman-Ubbels, G.H.J., Swart, C.P., Leonards, P.E.G. & Legler, J. (2006 augustus 24). Applications of in vitro screening tools to support risk assessment of brominated flame retardants. Oslo, Norway, 26^th International Symposium on Halogenated Environmetnal Organic Pollutants and Persistent Organic Pollutants (POPs) – “DIOXIN 2006” (voordracht-lezing).

Harks, E.G.A., A.D.G. de Roos, P.H.J. Peters, L.H. de Haan, A. Brouwer, D.L.Ypey, E.J.J. van Zoelen, A.P.R. Theuvenet (2001). Fenamates: A novel class of reversible gap junction blockers. J. of Pharmacology and Experimental Therapeutics, Vol. 298, No. 3, pp. 1033-1041.

Heath-Pagliuso, S., W.J. Rogers, K. Tullis, et al. (1998). Activation of the Ah receptor by trypto­phan and tryptophan metabolites, Biochem., in press.

Heussen, G.A.H., M.L.J.Hikspoors, A.Spenkelink, et al. (1992). Inhibition of binding thyroxin to transthyretin by outdoor and indoor airborne particulate matter and effects on thyroid hormone and vitamin A metabolism in rats, Arch. Environ. Contam. Toxicol. 23, 6-12.

Heussen, G.A.H., G.J. Schefferlie, M.J.G. Talsma, et al. (1993). Effects on thyroid hormone meta­bolism and depletion of lung vitamin A in rats by airborne particulate matter, J. Toxicol. & Environm. Health, 38, 419-34.

Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Hakansson H. (2005). Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms. Chem Biol Interact. 2005 Sep 10;156(1):25-39.

Hoogenboom, L.A.P., L. de Haan, D. Hooijerink, G. Bor, A.J. Murk and A. Brouwer (2001). Estrogenic activity of estradiol and its metabolites in the ER-CALUX assay with human T47D breast cells. APMIS 109, pp. 101-107.

Hoogenboon, L.A.P., L. De Haan, D. Hooijerink, G. Bor, A.J. Murk and A. Brouwer (2001) Estrogenic activity of estradiol and its metabolites in the ER-CALUX assay with human T47D breast cells. Apmis, 109: S480-S486.

Houtman CJ, Booij P, van der Valk KM, van Bodegom PM, van den Ende F, Gerritsen AA, Lamoree MH, Legler J, Brouwer A. (2007). Biomonitoring of estrogenic exposure and identification of responsible compounds in bream from Dutch surface waters. Environ Toxicol Chem.;26(5):898-907.

Houtman CJ, Booij P, Jover E, Pascual del Rio D, Swart K, Van Velzen M, Vreuls R, Legler J, Brouwer A, Lamoree MH (2006). "Estrogen and dioxin-like compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analyses." Chemosphere 65: 2244-2252.

Houtman, C.J., A.M. Van Oostveen, A. Brouwer, M.H. Lamoree, J. Legler (2004). Identification of estrogenic compounds in fish bile using bioassay-directed fractionation. Environ Sci Technol. 2004 Dec 1;38(23):6415-23.

Houtman, C.J., Cenijn, P.H., Hamers, T.H.M., Lamoree, M.H., Legler, J., Murk, A.J. & Brouwer, A. (2004). Toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruption. Environmental Toxicology and Chemistry, 23(1), 32-40.

Houtman, C.J., Jover, E., Adahchour, M., Lamoree, M., Legler, J. & Brouwer, A. (2004). Identification of dioxin-like and estrogenic compounds in sediment using calux® assay-directed fractionation combined with two-dimensional comprehensive gcxgc-tof ms. Organohalogen Compounds, 66, 691-697.

Houtman, C.J., Van Houten, Y.K., Leonards, P.E.G., Brouwer, A., Lamoree, M.H., & Legler, J. (2006). Biological validation of a sample preparation method for ER-CALUX bioanalysis of estrogenic activity in sediments using mixtures of xeno-estrogens. Environmental Science and Technology, 40(7), 2455-61.

Jeuken, A., Keser, B.J.G., Khan, E., Brouwer, A., Koeman, J. & Denison, M.S. (2003) Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables and fruits. Journal of agricultural and food chemistry. 51, 5478-5487.

Jonas, A.J.G., Besselink, H.T., & Brouwer, A. (2005). Introduction of a linear 2,3,7,8-TCDD curve-fit as a means to Improve performance characteristics of the. Organohalogen Compounds, 67, 62-65.

Kendall, R.J., A. Brouwer, J.P. Giesy, et al. (1998). Wildlife conservation concerns and a mecha­nistic foundation for endocrine disruption in wildlife: a risk-based field and laboratory approach to assess health. Chapter 1, in: Principles and processes for evaluating endocrine disruption in wildlife, eds. R.J. Kendall, R.L. Dickersan, W.A. Suk and J.P. Giesy) SETAC Press series, 1-16.

Kester, M.H., Bulduk, S., Toor, H. van, Tibboel, D., Meinl, W., Glatt, H., Falany, C.N., Coughtrie, M.W., Schuur, A.G., Brouwer, A. & Visser, T.J. (2002). Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters. Journal of Clinical Endocrinological Metabolism, 87(3), 1142-50.

Koopman-Esseboom, C., M.Huisman, N.Weisglas-Kuperus, et al. (1992). Effects of PCBs and Di­oxins during pregnancy and breast feeding on growth and development of newborn infants. A study design and preliminary results. Organohalogen Compounds, 10, 265-9.

Koopman-Esseboom, C., D.C. Morse, N. Weisglas-Kuperus, et al. (1994). Effects of dioxins and polychlorinated biphenyls on throid hormone status of pregnant women and their children, Pediatr. Res., 36, 468-73.

Koppen, G., A. Covaci, R. van Cleuvenbergen, P. Schepens, G. Winneke, V. Nelen, A. Brouwer and G. Schoeters (2001). Comparison of CALUX-TEQ values with PCB and PCDD/PCDF measurements in human serum of the Flanders Environmental and Health Study (FLEHS). (journal still to be chosen: EHP, Environ Chem Toxicol or another journal Toxicol-based).

Kuil, C.W., A. Brouwer, K.B. Horwitz, et al. (1998). Interference between progesterone and dioxin signal transduction pathways: different mechanisms are involved in repression by the progeste­rone receptor A and B isoforms. J. Biol. Chem., in press.

Lans, M.C., A. Brouwer, J.C. Koppe, et al. (1990). Enzyme induction and alterations in thyroid hormone, vitamin A and K levels by TCDD in neonatal and maternal rats. Chemosphere, 20(7-9), 1129-35.

Lans, M.C., I. Brouwer, M. Beukers, et al. (1996). In vivo alterations in thyroxine metabolism and plasma transport by Aroclor 1254 in rats. Toxicology, accepted.

Lans, M.C., I. Brouwer, P. de Winden, et al. (1993). Different effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and Aroclor 1254 on thyroxine metabolism and transport. Organohalogen Compounds 13, 137-40.

Lans, M.C., A. Damas, C.C.F. Blake, et al. (1996). Structural basis for the binding of hydroxylated polychlorobiphenyl (PCB) metabolites to human transthyretin. J. Biol. Chem., submitted.

Lans, M.C., P. de Winden, M. Beukers, et al. (1996). In vivo alterations in thyroxine metabolism and plasma transport by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats. Toxicology, submitted.

Lans, M.C., E. Klasson-Wehler, and A. Brouwer (1994). Thyroid hormone binding proteins as tar­gets for hydroxylated PCB, PCDD and PCDF metabolites; an overview, Organohalogen Com­pounds, 20, 481-5.

Lans, M.C., E. Klasson-Wehler, E. Meussen, et al. (1996). In vitro inhibition of thyroxine type 1 dei­odinase by hydroxylated polychlorinated biphenyls, -dibenzo-p-dioxins and -dibenzofurans. Chem.-Biol. Interact., accepted.

Lans, M.C., E. Klasson-Wehler, M. Willemsen, et al. (1993). Structure-dependent, competitive inter­action of hydroxy-polychlorobiphenyls, -polychlorodibenzo-p-dioxins and –polychlorodibenzo­furans with human transthyretin. Chemico-Biol. Interact., 88, 7-21.

Lans, M.C., G. Kubiczak, J. Douwes, et al. (1990). In vitro effects of 3,4,3’,4’-tetrachlorobiphenyl and its hydroxy-metabolites on mitochondrial function. In:10th International Meeting on Dioxins, 1990 Bayreuth, W-Germany, vol. 1, 103-6, Ecoinforma Press, Bayreuth.

Lans, M.C., C. Spiertz, A. Brouwer, et al. (1994). Differential, competitive interaction of hydroxy-PCBs, PCDDs and PCDFs with transthyretin (TTR) and thyroxine-binding globulin (TBG). Eur. J. Pharmacol.: Environ. Toxicol. & Pharmacol. section, 270, 129-36.

Lans, M.C., M. van den Berg, and A. Brouwer (1989). Verlaging van retinoidegehalten in de lever van pasgeboren ratten door blootstelling aan 2,3,7,8-tetrachlorodibenzo-p-dioxine via moeder­melk. Voeding 50 (6/7), 202-3.

Legler, J & Brouwer, A. (2003). Are brominated flame retardants endocrine discruptors? Environment International. 29(6), 879-885.

Legler, J., Dennekamp, M., Vethaak, A.D., Brouwer, A., Koeman, J.H., Burg, B. van der & Murk, A.J. (2002). Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays. Science of the Total Environment, 3;293(1-3), 69-83.

Legler, J., Lanser, P.H., Brouwer, A., Vethaak, D., de Voogt, P., Murk, A.J. & van der Burg, B.(2001). Application of in vitro and in vivo reporter gene assays for assessing (mixtures of ) estrogenic substances.

Legler, J., L. Bouwman, A.J. Murk, et al. (1996). Determination of dioxin- and estrogen-like activity in sediment extracts using in vitro CALUX assays. Organohalogen Compounds 29, 347-52.

Letcher, R.J., Lemmen, J.G., Burg, B. van der, Brouwer, A., Bergman, A., Giesy, J.P. & Berg M. van den (2002). In vitro anti estrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17beta-estradiol-induced gene expression in several bioassay systems. Toxicological Sciences, 69(2), 362-72.

Lipzig, M.M. van, Commandeur, J.N.M., Kanter, F.J.J. de, Damsten, M.C., Vermeulen, N.P.E., Maat, E., Groot, E.J., Brouwer, A., Kester, M.H.A., Visser, T.J., & Meerman, J.H.N. (2005). Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity. Chemical Research in Toxicology, 18(11), 1691-1700.

Lund, B.O., J. Orberg, A. Bergman, et al. (1998). Chronic and reproductive toxicity of a mixture of 15 methylsulfonyl-PCBs and 3-methylsulfonyl-DDE in mink (Mustela vison), Envirnom. Toxicol. & Chem., in press.

Meerts, I.A.T.M., Lilienthal, H., Hoving, S., Berg, J.H.J. van den, Weijers, B.M., Bergman, A., Koeman, J.H. & Brouwer, A. (2004). Developmental exposure to 4-hydroxy-2,3,30,40, 5-pentachlorobiphenyl (4-OH-CB107): long-termeffects on brain development, behavior, and brain stem auditory evoked potentials in rats. Toxicological Sciences, 82, 207-218.

Meerts, I.A.T.M., Hoving, S., Berg, J.H.J. van den, Weijers, B.M., Swarts, H.J., Beek, E.M. van der, Bergman, A., Koeman, J.H. & Brouwer, A. (2004). Effects of in utero exposure to 4-hydroxy-2,3,30,40, 5-pentachlorobiphenyl (4-OH-CB107) on developmental landmarks, steroid hormone levels, and female estrous cyclicity in rats. Toxicological Sciences, 82, 259-267.

Meerts, I.A, Assink, Y., Cenijn, P.H., Berg, J.H. van den, Weijers, B.M., Bergman, A., Koeman, J.H. & Brouwer, A. (2002). Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicological Sciences, 68(2), 361-71.

Meerts, I.A.T.M., Lilienthal, H., Seegal, R.F., Brosch, K.O., Saske Hoving, van den Berg, J.H.J, Weijers, B.M., Bergman, A., Koeman, J.H. & Brouwer, A. (2001, to be submitted). Developmental Exposure to 4-hydroxy-2,3,3’,4’,5-pentachlorobiphenyl (4-OH-CB107): Long Term Effects on Brain Development, Behavior and Brain Stem Auditory Evoked Potentials in Rats

Meerts, Ilonka A.T.M., R$obert J. Letcher, Saske Hoving, Göran Marsh, Ake Bergman, Josephine G. Lemmen, Bart van der Burg, and Abraham Brouwer (2001). In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polibrominated bisphenol A compounds. Enviornmental health perspectives, 109(4), pp. 399- 407.

Meijer, L., Weiss, J., Van Velzen, M., Brouwer, A., Bergman, A. & Sauer, P. (2004). Flame retardants, polychlorinated biphenyls and insecticides in pregnant women in the northern part of the Netherlands. Organohalogen Compounds, 66, 3503-3507.

Mekenya, O., Kamenska, V., Serafimova, R., Poellinger, L., Brouwer, A. & Walker, J. (2002). Development and validation of an average mammalian estrogen receptor-based QSAR model. SAR QSAR Environmental Research, 13(6), 579-95.

Mensink, A., A. Brouwer, E.H. van den Burg, et al. (1996). Modulation of intercellular communica­tion between smooth muscle cells by growth factors and cytokines. Eur. J. Pharmacol. 310, 73-81.

Morse, D.C., and A. Brouwer (1995). Fetal, neonatal and longterm alterations in hepatic retinoid levels following maternal polychlorinated biphenyl exposure in rats, Toxicol. Appl. Pharmacol. 131, 175-82.

Morse, D.C. and A. Brouwer (1994). Perinatal alterations of thyroid hormone homeostasis and long-term neurochemical alterations in rats following maternal Aroclor 1254 exposure, Organohalo­gen Compounds, 21, 439-43.

Morse, D.C., A. Brouwer, and E. Klasson-Wehler (1994). Perinatal accumulation of hydroxylated polychlorobiphenyl metabolites in rats following maternal Aroclor 1254 exposure, Organoha­logen Compounds 20, 513-6.

Morse, D.C., A.Th.H.J. de Bie, P.J. van Bladeren, et al. (1990). Excretion kinetics of a combined dose of 3,3’,4,4’-tetrachlorobiphenyl and 2,4,5,2’,4’,5’-hexachlorobiphenyl in female rats. In:10Th International meeting on Dioxins, 1990 Bayreuth, W-Germany) vol 1, 39-42, Eco­informa Press, Bayreuth.

Morse, D.C., R. Dekkers, H. Hokse, et al. (1996). Induction of glutamine synthetase activity in primary astrocytes by Aroclor 1254 and 2,3,7,8-tetrachlorodibenzo-p-dioxin Organohalogen Compounds 29, 152-5.

Morse, D.C., D. Groen, M. Veerman, et al. (1993). Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicol. Appl. Pharmacol., 122, 27-33.

Morse D.C., H.B.W.M. Koeter, A.E.Smits van Prooijen, et al. (1992). Interference of polychlorina­ted biphenyls in thyroid hormone metabolism: possible neurotoxic consequences in fetal and neonatal rats. Chemosphere, vol.25, nos.1-2, 165-8.

Morse, D.C., E. Klasson-Wehler, M. van de Pas, et al. (1995). Metabolism and biochemical effects of 3,3’,4,4’-tetrachlorobiphenyl in pregnant and fetal rats. Chem.-Biol. Interact. 95, 41-56.

Morse, D.C., E. Klasson-Wehler, W. Wesseling, et al. (1996). Alterations in rat brain thyroid hor­mone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol Appl. Pharmacol. 136, 269-79.

Morse, D.C., A. Plug, W. Wesseling, et al. (1996). Persistent alterations in regional brain glial fibrillary acidic protein and synaptophysin levels following pre- and postnatal polychlorinated biphenyl exposure. Toxicol. Appl. Pharmacol. 139, 252-61.

Morse, D.C., R.F. Seegal, K.O. Brosch, et al. (1997). Long-term alterations in regional brain sero­tonin metabolism following maternal polychlorinated biphenyl exposure in the rat. Neurotoxico­logy, 17 (3/4) 631-8.

Morse, D.C., P.J. van Bladeren, E. Klasson-Wehler, et al. (1995). ß-Naphthoflavone- and self-indu­ced metabolism of 3,3’,4,4’-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant fe­male and foetal rat, Xenobiotica, 25 (3), 245-60.

Morse, D.C., W. Wesseling, A. Brouwer, et al. (1993). Prenatal Aroclor 1254 exposure selectively alters regional Glial Fibrillary Acidic Protein levels in the rat brain. Organohalogen Compounds, 14, 73-6.

Murk, A.J., A.T.C. Bosveld, M. van den Berg, et al. (1994). Effects of polyhalogenated aromatic hydrocarbons (PHAHs) on biochemical parameters in chicks of the common tern (Sterna hirun­do), Aquatic Toxicol., 30, 91-115.

Murk, A.J., A. Jonas, A. Brouwer, et al. (1996). Application of the CALUX (chemical activated luciferase gene expression) assay for measuring TCDD_equivalents in sediment, pore water and blood plasma samples. Organohalogen Compounds 27, 291-6.

Murk, A.J., J. Legler, M.S. Denison, et al. (1996). Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fund. & Appl. Toxicol. 33, 149-60.

Murk, A.J., J. Legler, M.S. Denison, et al. (1996). The CALUX assay: a novel recombinant DNA in vitro bioassay as a biomarker for Ah-receptor active compounds in environmental matrices. Fund. & Appl. Toxicol., 33, 149-60.

Murk, A.J., P.E.G. Leonards, A.S. Bulder, et al. (1997). The Calux (chemical activated luciferase expression) assay adapted and validated for measuring TCDD equivalents in blood plasma. Environm. Toxicol. & Chem. 16 (8), 1583-9.

Murk. A.J., D.C. Morse, J. Boon, et al. (1994). In vitro metabolism of 3,3’,4,4’-tetrachlorobiphenyl in relation to ethoxyresorufin-o-deethylase activity in liver microsomes of some wildlife species and rat, Eur. J. Pharmacol: Environ. Toxicol. Pharmacol section, 270, 253-61.

Murk, A.J., D.C. Morse, E. Klasson-Wehler, et al. (1993). In vitro metabolism of 3,4,3’,4’-tetra­chlorobiphenyl by microsomes of wildlife species compared to the rat. Organohalogen Com­pounds, 14, 207-10.

Murk, A.J., M.J.C. Rozemeijer, J.P. Boon, et al. (1993). Vitamin A reduction in Eider Ducklings (Somateria mollissima) exposed to polychlorinated biphenyls (CB-77 and Clophen A50), Organohalogen Compounds, 14, 59.

Murk, A.J., J.H.J. van den Berg, M. Fellinger, et al. (1994). Toxic and biochemical effects of 3,3’,4,4’-tetrachlorobiphenyl (CB-77) and Clophen A-50 on eider ducklings (Somateria mollis­sima) in a semi-field experiment, Environ. Pollut., 86, 21-30.

Murk, A.J., J.H.J. van den Berg, J.H. Koeman, et al. (1990). Comparative toxicity study of Tetra­chlorobenzyltoluenes (Ugilec 141) and Polychlorobiphenyls (Aroclor 1254 and PCB-77) in Ah-responsive (C57BL/6) and Ah-nonresponsive (DBA/2) mice. In: 10th International Meeting on Dioxins, 1990, Bayreuth, W-Germany, vol 1, 199-202, Ecoinforma Press, Bayreuth.

Murk, A.J., J.H.J. van den Berg, J.H. Koeman, et al. (1990). In: LAC workshop Ugilec, December 1990, Wageningen, pp 21-38.

Murk, A.J., J.H.J. van den Berg, J.H. Koeman, et al. (1991). The toxicity of tetrachlorobenzyl­toluenes (Ugilec 141) and polychlorobiphenyls (Aroclor 1254 and PCB-77) compared in Ah-responsive and Ah-nonresponsive mice. Environmental Pollution 72, 57-67.

Pauwels, A., P.J. Schepens, T. D’Hooghe, L. Delbeke, M. Dhont, A. Brouwer and J. Weyler (2001). The risk of endometriosis and exposure to dioxins and polychlorinated biphenyls: a case-control study of infertile women. Human Reproductio, Vol. 16, No. 10, pp.2050-2055.

Ross, P.S., R.L. de Swart, H. van der Vliet, et al. (1997). Impaired cellular immune response in rats exposed perinatally to Balticsea herring oil or 2,3,7,8-TCDD. Arch. Toxicol., 71 (9), 563-74.

Ross, P.S., H. van Loveren, R.L. de Swart, et al. (1996). Host resistance to rat cytomegalovirus (RCMV) and immune function in adult PVG rats fed herring from the contaminated Baltic Sea. Arch. Toxicol., 70, 661-71.

Rozemeijer, M.J.C., J.P.Boon, P. Duiven, et al. (1992). The effect of 3,3?,4,4?-tetrachlorobiphenyl and Clophen A50 on the Hepatic Monooxygenase System of Eider Ducklings (Somateria mollis­sima) with Indications for structure-related biotransformation of PCB Congeners. Marine Env. Research 34, 207-13.

Rozemeijer, M.J.C., J.P. Boon, C.Swennen, et al. (1995). Dioxin type and mixed type induction of the cytochromeP-450 system of common eider ducklings (Somateria mollissima) by PCBs: with indications for biotransformation. Aquatic Toxicology 1995, 32, 93-113.

Sandau, C.D., I. Meerts, R.J. Letcher, A.J. McAlees, B. Chittim, A. Brouwer and R.J. Norstrom (2000) Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transthyretin: A metabolite of octachlorostyrene? Environmental Science & Technology, 34(18): 3871-3877.

Sanderson, J.T., J.M.M.J.G. Aarts, A. Brouwer, et al. (1996). Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-o-deethylase induction in H4IIe cells: implications for the detec­tion of polyhalogenated aromatic hydrocarbons. Toxicol. Appl. Pharmacol., 137, 316-25.

Sauer, P.J.J., M. Huisman, C. Koopman-Esseboom, et al. (1994). Effects of polychlorinated biphe­nyls (PCBs) and dioxins on growth and development, Human & Exp. Toxicol., 13, 900-6.

Schalk, J.A.C., M.A. Cox, J.M.M.J.G. Aarts, et al. (1993). Species-specific antagonism of Ah recep­tor action by 2,2’,5,5’-tetrachlorobiphenyl. Organohalogen Compounds, 14, 137-40.

Schets, F.M., Nobel, P.J., Strating, S., Mooijman, K.A., Engels, G.B. & Brouwer, A. (2002). EU Drinking Water Directive reference methods for enumeration of total coliforms and Escherichia coli compared with alternative methods.Letters in Applied Microbiology, 34(3), 227-31.

Schmidt, C.K., Brouwer A. & Nau, H. Chromatographic analysis of endogenous retinoids in tissues and serum. Analytical Biochemistry (2003). 315(1), 36-45.

Schreurs RH, Sonneveld E, van der Saag PT, van der Burg B, Seinen W. (2005). Examination of the in vitro (anti)estrogenic, (anti)androgenic and (anti)dioxin-like activities of tetralin, indane and isochroman derivatives using receptor-specific bioassays. Toxicol Lett. 2005,156:261-75.

Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B. (2005). Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005, 83:264-72.

Schuur, A.G., F.M. Boekhorst, A. Brouwer, et al. (1997). Extrathyroidal effects of 2,3,7,8-tetrachlo­rodibenzo-p-dioxin on thyroid hormone turnover in male Sprague-Dawley rats. Endocrinol. 138 (9), 3727-34.

Schuur, A.G., A. Brouwer, A. Bergman, et al. (1998). Inhibition of thyroid hormone sulfation by hydroxylated metabolites of polychlorinated biphenyls. Chem-Biol. Interact. 109, 293-7.

Schuur, A.G., F.F. Legger, M.E. van Meeteren, et al. (1998). In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons. Chem. Res. Toxicol., in press.

Schuur, A.G., P.J. Tacken, T.J. Visser, et al. (1998). Modulating effects of thyroid state on the induction of biotransformation enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environm. Toxicol. & Pharmacol. 5, 7-16.

Schuur, A.G., M.E. van Meeteren, W.M.C. Jong, et al. (1996). Inhibition of thyroid hormone sulfa­tion by hydroxylated metabolites of polychlorinated biphenyls in vitro. Organohalogen Com­pounds 28, 509-12.

Soechitram, S.D., Chan, S.M., Nelson, E.A., Brouwer, A. & Sauer, P.J. (2003). Comparison of dioxin and PCB concentrations in human breast milk samples from Hong Kong and the Netherlands. Food, Additives and Contaminants. 2003, 20(1), 165-169.

Soechitram, S.D., S.M. Chan, E.A.S. Nelson, A.Brouwer, P.J.J. Sauer (2001 submitted). Comparison of dioxin and PCB concentration in hyman breast milk between Hong Kong and The Netherlands. Envir. Health Perspectices.

Sonneveld, E., Riteco, J.A.C., Jansen, H.J., Pieterse, B., Brouwer, A., Schoonen, W.G., Van der Burg, B. (2006). Comparison of in vitro and in vivo screening models for androgenic and estrogenic activities. Toxicol. Sci., 89: 173-187.

Sonneveld, E, Jansen, HJ, Man, S, Jonas, A, Brouwer, A and Van der Burg, B. (2006). Glucocorticoid mediated expression of dioxin target genes in rat H4IIe cells but not in human HepG2 and T47D cells..Organohalogen Compounds.in press.

Sonneveld E, Jansen HJ, Riteco JA, Brouwer A, van der Burg B. (2005). Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci. 2005, 83:136-48. 

Sonneveld Edwin, Jacoba A. C. Riteco, Hendrina J. Jansen, Bart Pieterse, Abraham Brouwer, Willem G. Schoonen, and Bart van der Burg (2005). Comparison of In Vitro and In Vivo Screening Models for Androgenic and Estrogenic Activities. Toxicological Sciences (accepted).

Sonneveld, E., Jansen, J., Riteco, N, Brouwer, A. & Burg, B. van der (2003). Calux® reporter cell lines as sensitive bioassay for monitoring biological activity of various classes of steroid hormones revert the repressive effect of TCDD on the estrogen receptor. Organohalogen Compounds, 60, pp 263-266.

Stern, N., Oberg, M., Casabona, H., Trossvik, C., Manzoor, E., Johansson, N., Lind, M., Orberg, J., Feinstein, R., Johansson, A., Chu, I., Poon, R., Yagminas, A., Brouwer, A., Jones, B. & Hakansson, H. (2002). Subchronic toxicity of Baltic herring oil and its fractions in the rat II: Clinical observations and toxicological parameters. Pharmacology & Toxicology, 91(5), 232-44.

Takigami H, Sakai S, Brouwer A. (2005). Bio/chemical analysis of dioxin-like compounds in sediment samples from Osaka Bay, Japan. Environ Technol. 2005 Apr; 26(4):459-69.

Van Birgelen, A.P.J.M., I. Bol, et al. (1993). Apparent antagonistic effects between 3,3’,4,4’,5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic retinoid loss in the rat: possible involvement of CYP1A2. Organohalogen Compounds, 13, 141-4.

Van Birgelen, A.P.J.M., K.M. Fase, J. van der Kolk, et al. (1995). Synergistic Effect of 2,2?,4,4?,5, 5?-Hexachlorobiphenyl and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Hepatic Porphyrin Levels in Female Sprague-Dawley rats. Compounds 25, 105-10.

Van Birgelen, A.P.J.M., K.M. Fase, J. van der Kolk, et al. (1996). Synergistic Effects of 2,2’,4,4’,5, 5’-Hexachlorobiphenyl and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Hepatic Porphyrin Levels in the rat.. Health Perspect. 104 (5), 550-7.

Van Birgelen, A.P.J.M., J.M.W. Smeets, C.M. Fase, et al. (1993). Apparent antagonistic effects between 2,3,3’,4,4’,5-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on CYP1A1, CYP1A2 activities, and in vitro metabolism of 3,3’,4,4’-tetrachlorobiphenyl: role of target tissue concentration. Organohalogen Compounds, 13, 187-90.

Van Birgelen, A.P.J.M., E.A. Smit, I. Bol, et al. (1993). Subchronic effects of 2,3,3’,4,4’,5-hexa­chlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone and retinoid metabo­lism:possible role of cytochrome P450 and UDP-Glucuronyltransferases. Organohalogen Compounds, 13, 321-4.

Van Birgelen, A.P.J.M., E.A. Smit, I.M. Kampen, et al. (1995). Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment. European Journal of Pharma­cology, Environmental Toxicology and Pharmacology Section 293, 77-85.

Van Birgelen, A., J. van der Kolk, K. Fase, et al. (1992). Can vitamin A be used in the risk assess­ment of dioxins and related compounds? Voeding 53 (7,8), 183-7.

Van Birgelen, A.P.J.M., J. van der Kolk, K.M. Fase, et al. (1995). Subchronic Dose Response Study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Female Sprague-Dawley rats, Toxicology and Applied Pharmacology 1995, 132, 1-13.

Van Birgelen, A.P.J.M., J. van der Kolk, K.M. Fase, et al. (1995). Subchronic Dose-Response Study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Female Sprague-Dawley rats. Toxicology and Applied Pharmacology 1995, 132, 43.

Van Birgelen, A.P.J.M., J. van der Kolk, K.M. Fase, et al. (1995). Subchronic Dose-Response Study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Female Sprague-Dawley rats. Organohalogen Co­mpounds 25, 207-12.

Van Birgelen, A., J. van der Kolk, K. Fase, et al. (1992). Toxicity and biochemical potencies of po­lychlorinated biphenyl congeners relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin in three months feeding studies in the rat. Organohalogen Compounds, 10, 373-6.

Van Birgelen, A.P.J.M., J. van der Kolk, K.M. Fase, et al. (1994). Toxic potency of 2,3,3’,4,4’,5-hexachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feedingstudy in the rat, Toxicol. Appl. Pharmacol., 126, 202-13.

Van Birgelen, A.P.J.M., J. van der Kolk, K.M. Fase, et al. (1994). Toxic potency of 3,3’,4,4’,5-pentachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat. Toxicol. Appl. Pharmacol., 127, 209-21.

Van Birgelen, A.P.J.M., J. van der Kolk, H. Poiger, et al. (1992). Interactive effects of 2,2’,4,4’,5,5’-hexachlorobiphenyl and 2,3,7,8-TCDD on thyroid hormone, vitamin A and vitamin K metabo­lism in the rat. Chemosphere, 25, 1239-44.

Van Birgelen, A.P.M.J., J.van der Kolk, H.Poiger, et al. (1992). Interactive effect of 2,2’,4,4’,5,5’-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in the rat. Voeding 53 (7,8), 213.

Van den Berg, K.J., and A. Brouwer (1981). Early decrease of retinol levels in mice after exposure to low doses pf polychlorinated biphenyls Ann. Rep. TNO, 97-9.

Van den Berg, K.J., and A. Brouwer (1982). Vitamine A: een antipromotor van carcinogenese; PCBs: anti-antipromotors? IKR Bulletin, oktober.

Van den Berg, M., B.L.H.J. Craane, T. Sinnige, et al. (1994). Biochemical and toxic effects of poly­chlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in the cormorant (Phalacrocorax carbo) after in ovo exposure, Environ. Toxicol. Chem., 13 (5), 803-16.

Van den Berg, M., B.L.H.J. Craane, Th. Sinnige, et al. (1991). The use of biochemical parameteres in comparative toxicological studies with fresh-eating birds in the Netherlands. Proc. of 11th Ann. Symp. on chlorinated Dioxins and Related Compounds, Research Triangle Park USA, 23-7.

Van den Berg, M., L.H.J.Craane, S.van Mourik, et al. (1995). The (possible) impact of chlorinated dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) on the reproduction of the cor­morant Phalacrocorax carbo - an ecotoxicological approach. Ardea, 83: 299-313.

Van den Berg, M., L.H.J. Craane, S. van Mourik, et al. (1991). The possible impact of chlorinated dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (_CBs) on the reproduction of the cormorant: an ecotoxicological approach. In: Proc. of a Workshop on Cormorants (Phalae­rocrocorax carbo), M.R. van Eerden and M. Zijlstra (eds), 219-30.

Van den Berg, K.J., C. Zurcher, and A. Brouwer (1988). Effects of 3,4,3’,4’-tetrachlorobiphenyl on thyroid function and histology in marmoset monkeys Toxicol. Letters, 41, 77-86.

Van den Berg, K.J., C. Zurcher, and A. Brouwer (1984) .Toxicity of 3,4,3’,4’-tetrachlorobiphenyl in marmosets. Ann. Rep. TNO, 51-4.

Van den Berg, K.J., C. Zurcher, A. Brouwer, et al. (1988). Chronic toxicity of 3,4,3’,4’-tetrachloro­biphenyl in the marmoset monkey (Callithrix Jacchus). Toxicol. 48, 209.

Van der Gaag, M., M. van den Berg, A. Brouwer, et al. (1991). Impaired breeding success of some Cormorant populations in the Netherlands: the net tightens around compounds with a dioxin-like effect. In: J.A.W. de Wit, M.A. van der Gaag, C. van der Guchte, C.J. van Leeuwen and J.H. Koeman (eds): The effect of micropollutants on components of the Rhine ecosystem. Publikaties en rapporten van het project ‘Ecologisch Herstel Rijn’ no. 35, 1991, 71-7.

Van der Plas, S.A., A. Brouwer, M. Haag-Gronlund, et al. (1996). Non-additive inductions of altered hepatic foci in female Sprague-Dawley rats by a mixture of dioxin-like compounds. Organohalogen Compounds 29, 233-7.

van der Plas, S.A., H. Sundberg, H. van den Berg, G. Scheu, P. Wester, S. Jensen, A. Bergman, J. de Boer, J.H. Koeman and A. Brouwer (2000) Contribution of planar (0-1 Ortho) and nonplanar (2-4 Ortho) fractions of aroclor 1260 to the induction of altered hepatic foci in female Sprague-Dawley rats. Toxicology and Applied Pharmacology, 169(3): 255-268.

van der Plas, S.A., I. Lutkeschipholt, B. Spenkelink and A. Brouwer (2001) Effects of subchronic exposure to complex mixtures of dioxin-like and non-dioxin-like polyhalogenated aromatic compounds on thyroid hormone and vitamin A levels in female Sprague-Dawley rats. Toxicological Sciences, 59(1): 92-100.

Van Velzen, M.J.M., Horst, A. van der & Brouwer, A. (2004). De bepaling van hydroxy-PCB's en aanverwante stoffen in humaan serum, OH-PCBRD. IVM (Int. r. no. L-04/02). Dept. of Chemistry and Biology, 24 pp.

Visser, T.J., E. Kaptein, H. van Toor, et al. (1993). Glucuronidation of Thyroid hormone in rat liver: Effects of in vivo treatment with microsomal enzyme inducers and in vitro assay conditions. Endocrinol., 133 (5), 2177-86.

Wagemaker, G., and A. Brouwer (1978). Isolation and purification of specific glycoprotein factors acting on primitive haemopoietic cells. Ann. Rep. TNO, 61-3.

Wagemaker, G., A. Brouwer, and M.F. Peters (1976). Isolation of colony stimulating factor (CSF) from pregnant mouse uterus extract (PMUE). Ann. Rep. TNO, 224-6.

Wagemaker, G., A. Brouwer, and M.F. Peters (1976). Properties of human leucocyte conditioned medium (HLCM). Isolation of activities. Ann. Rep. TNO, 227-30.

Wagemaker, G., T.P. Visser, and A. Brouwer (1978). Induction of erythropoietin responsiveness in vitro by a specific glycoprotein factor. Ann. Rep. TNO, 57-60.

 

5)  Pesentations 2004-2006

March 19 -21, 2006. ESBIO Conference on Human Biomonitoring within Europe, Lisbon. Fast, low volume methods for human monitoring of anabolic agents and endocrine disrupting compounds.

May 22-26, 2006. Asian Mission. A low volume method for the analysis of dioxins and dioxin-like compounds in serum using BDS’ DR CALUX^® bioassay: Method validation, Case Study Victor Yushchenko.

May 22-26, 2006. Asian mission. CALUX^® Biodetectors: Emerging Needs, Emerging Technologies.

Juni 21, 2006. Toxicogenomics Meeting, Vught, The Netherlands. Approaches to development of alternative test systems within Ecogenomics.

August 17-18, 2006. 1st CALUX Exchange Workshop 2006, Amsterdam. “CALUX 2006: Business & Technology Development”.

August 22, 2006. Dioxin 2006, Oslo. “Glucocorticoid mediated expression of dioxin target genes through regulation of the aryl hydrocarbon receptor in rat H4IIE cells but not in human HEPG2 and T47D cells”.

March 18, 2005. Lecture for students, Vrije Universiteit. “Biotransformation or Metabolism of Compounds” (synopsis in Dutch).

March 21, 2005. Lecture for students, Vrije Universiteit. “Dioxins and dioxin-like Compounds” (synopsis in Dutch).

March 22, 2005. Lecture for students, Vrije Universiteit. “Risk Assessment of Compounds” (synopsis in Dutch).

April 22, 2005. 1st Annual Meeting of the Ecogenomics Research Program, Amsterdam. “Assessing the Living Soil”.

May 25-27,  2005. EIRMA Annual Conference, Copenhagen. “Open Innovation: An Effective Strategy for Growth and Expansion”.

June 27, 2005. Pharmacochemie seminar, Vrije Universiteit, Amsterdam. “Bioanalysis with Genomics-based tools”.

August 22-26, 2005. Dioxin 2005, Toronto, Canada. “Observation of an extremely high dioxin level in a human serum sample from Ukraine by DR CALUX^®, confirmed to be 2,3,7,8-tetrachlorodibenzo-p-dioxin by GC-HRMS”.

September 12, 2005. Kennisintensief Ondernemen SPA, Amsterdam. “Kennisintensief Ondernemen op het Science Park Amsterdam (SPA)”.

September 14, 2005. Presentation Corus Group, Liddelborough, UK. “CALUX Biodetection for Dioxins”.

October 5, 2005. Momentum 2005, World Forum Convention Center, The Hague, The Netherlands. Genomics, Session 3: “Molecular Approaches to Define Healthy Soils Ecogenomics: What’s it all about?”

November 1st 2005. TACTRI meeting, Taiwan. “DR CALUX^® Bioassay: a novel method for analysis of Dioxins and Dioxin-like PCBs”.

November 14-15, 2005. EU-COMPARE Workshop, Brussel. “Testing developed and carried out in the COMPARE project”.

November 21, 2005. EU-Biomonitoring Workshop, Brussels. “Comparison of Exposure-Effect Pathways to Improve the Assessment of Human Health Risks of Complex Environmental Mixtures Of Organohalogens (COMPARE)”.

November 30, 2006. CIMO, Amsterdam. Lecture for students. “Kennisintensief Ondernemen op het Science Park Amsterdam (SPA)”.

December 7, 2005. Innovatie platform, Maarssen, The Netherlands. “Ecogenomics onderzoekt: nieuwe eigenschappen voor levende bodem”.

January 6, 2004. WICC, Wageningen. “ASSESSING THE LIVING SOIL - An ecogenomics approach to explore and unlock sustainable life-support functions of soils”.

March 31 – April 1, 2004. EURISKED/CREDO Workshop, Mallorca. “Possible long-term effects of  in utero exposure to organohalogen-type EDCs”.

August 26, 2004. EAL, Taiwan. “CALUX^® bioassays: New developments and applications”.

August 27, 2004. BFDA, Taiwan. “Dioxin Responsive DR CALUX^® Bioassay”.

December 1, 2004. Instituto di Medica, University Porto, Portugal. “A low volume method for the analysis of dioxins and dioxin-like compounds in serum using BDS’ DR CALUX® bioassay”.