Dioxins (polychlorinated dibenzodioxins; PCDDs) are one of the most toxic man-made
compounds known and can be measured by the DR CALUX®.
They are persistent environmental pollutants (POPs) and tend to accumulate
in biota. Dioxin-like compounds such as polychorinated biphenyls (PCBs) and polychlorinated
dibenzofurans (PCDFs) show similar properties. This group of chemicals, also known as
polyhalogenated aromatic hydrocarbons (PHAHs), display a wide variety of toxic effects in
mammals, birds, and fish. Among the toxic effects observed as a result of exposure to PHAHs
are immunotoxicity, carcinogenicity, metabolic changes, and even death.
Estrogens like Estradiol , a female sex hormone, has a direct effect on the function of the
reproductive system, the nervous system, the cardiovascular system and the skeletal system and can be measured by the ER CALUX®.
Blood sugar levels, skin and other tissues and functions are also significantly influenced
by estradiol. Like all steroid hormones, excessive amounts of estradiol can contribute to
a number of increased health risks. An increasing number of reports that chemicals in the
environment mimic the natural estrogen thereby disrupting normal endocrine function, have
raised public concern. It has been hypothesised that increased incidence of
hormone-sensitive cancers, decreased sperm counts in humans, and compromised gonadal
functionality in wildlife is due to exposure to substances possessing estrogenic activity.