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Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line.
Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures using in vitro recombinant receptor-reporter gene assays.
Bioassay analysis of mixtures of estrogenic and dioxin-like compounds.
Vertical profile of dioxin-like and estrogenic potencies in a sediment core from Tokyo Bay.
Evidence for estrogenic and TCDD-like activities in extracts of blood and semen of men.
Biological measurement of estrogenic activity in urine and bile conjugates with the in vitro ER CALUX reporter gene assay
Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays.
Value of in vivo transgenic zebrafish and in vitro reporter gene assays for determination of estrogenic activity in environmental matrices.
In vitro estrogenicity of brominated diphenyl ethers (PBDEs), hydroxylated PBDEs and polybrominated bisphenol A compounds.
Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays.
Estrogens and xeno-estrogens in the aquatic environment of The Netherlands: occurrence, potency and biological effects (LOES).
ERalpha-CALUX / Erbeta-CALUX</span
1. Kuiper, G.J.M., Lemmen, J.G., Carlsson, B., Corton, J.C., Safe, S.H., Van der Saag, P.T., Van der Burg, B., Gustafsson, J-A. (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor b. Endocrinol. 139, 4252-4263 .
2. Lemmen, J.G., Van den Brink, C.E., Legler, J., Van der Saag, P.T., Van der Burg, B. (2002) Detection of estrogenic activity of steroids present during mammalian gestation using ERa and ERß specific assays. J. Endocrinol. 174, 435-46.
3. Schreurs, H.M.M., Lanser, P., Seinen, W., Van der Burg, B. (2002) Estrogenic activity of UV screens determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay. Arch. of Toxicol.,76, 257-261.
4. Schreurs, H.M.M., Seinen, W., Van der Burg, B. (2002) Transcriptional activation of estrogen receptor a (ERa) and ERß by polycyclic musks is cell-type dependent, Toxicol. Applied Pharmacol. 15, 183-192.
5. Letcher, R.J., Brouwer, A., Van der Burg, B., Lemmen, J.G., Van den Berg, M. In vitro antiestrogenic effects of environmentally persistent methyl sulfone metabolites of 2,2',4,5'-Tetrachlorobiphenyl and 2,2',4,5,5'-Pentachlorobiphenyl: Inhibition of 17ß-estradiol-induced gene expression in several bioassay systems. Tox. Sciences., in press.
mER-CALUX</span
1. Lemmen, J.G., Arends, R.J., Van der Saag, P.T., Van der Burg, B. A mouse model to measure tissue-specific activity of estrogens and xeno-estrogens, in preparation.
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