Van der Burg, B., Van der Linden, S.C., Man, H.Y., Winter, R., Jonker, L., Van Vugt-Lussenburg, B., Brouwer, A. (2013) A panel of quantitative CALUX® reporter gene assays for reliable high throughput toxicity screening of chemicals and complex mixtures. In “High throughput screening methods in toxicity testing” (P. Steinberg, ed). John Wiley and Sons, Inc. New York. ISBN 9781118065631 pp. 519-532
Van Vugt-Lussenburg B, Van der Lee RB, Man HY, Middelhof I, Brouwer A, Besselink H, Van der Burg B. (2018) Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. Reproductive Toxicol., 75:40-48.
Van der Linden, SC, von Bergh A, Van Vugt-Lussenburg B, Jonker L, Brouwer A, Teunis M, Krul C and Van der Burg B. (2014) Development of a panel of high throughput reporter gene assays to detect genotoxicity and oxidative stress, Mutation Res.760,23-32.
Brussaard C, Peperzak L, Beggah S, Wick LY, Wuerz B, Weber J, Arey JS, Van der Burg B, Jonas A, Huisman J, Van der Meer JR. (2016) Immediate Ecotoxicological Effects of Short-Lived Marine Oil Spills Detected by Rapid on-site Biological Assays on Marine Biota. Nature Communications 7,11206-11216
Budin C, Man HY, Al-Ayoubi C, Puel S, van Vugt-Lussenburg BMA, Brouwer A, Oswald IP, van der Burg B, Soler L. (2021) Versicolorin A enhances the genotoxicity of Aflatoxin B1 in human liver cells by inducing the transactivation of the Ah-Receptor. Food Chem Toxicol 153,112258.
Lewin G, Escher SE, Van der Burg B, Simetska N, Mangelsdorf I (2015) Structural features of endocrine active chemicals – A comparison of in vivo and in vitro data. Reprod. Toxicol. 55,81-94
Suzuki G, Tue NM, van der Linden S, Brouwer A, van der Burg B, Lamoree M, van Velzen M, Someya M, Takahashi S, Isobe T, Tajima Y, Yamada T, Takigami H, Tanabe S (2011) Identification of major dioxin-like compounds and androgen receptor antagonist in Acid-treated tissue extracts of high trophic-level animals. Env Science & Technol., 45,10203-11
Van der Linden, S., Heringa, M.B., Man, H.Y., Sonneveld, E., Puijker, L., Brouwer, A., Van der Burg, B. (2008) Detection of multiple hormonal activities in waste water effluents and surface water, using a panel of steroid receptor CALUX bioassays, Environmental Science and Technology 42, 5814-20.
Schenk, B., Weimer, M., Bremer, S., Van der Burg, B., Cortvrindt, R., Freyberger, A., Lazzari, G., Cristian Pellizzer, Aldert Piersma, Wolfgang R. Schäfer, Andrea Seiler, Hilda Witters, Michael Schwarz. (2010) The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants. Reprod Toxicol. 30,200-18
Piersma AH, Schulpen SHW, Uibel F, Van Vugt-Lussenburg, B, Bosgra S, Hermsen SAB, Roelofs MJE, Man, H., Jonker, L., Van der Linden, S, Van Duursen MBM, Wolterbeek APM, , Schwarz M, Kroese ED, Van der Burg B. (2013) Evaluation of an alternative in vitro test battery for detecting reproductive toxicants. Reprod. Toxicol. 38,53-64.
Van der Burg B, Pieterse B, Buist H, Lewin G, Van der Linden SC, Man HY, Piersma AH, Rorije E, Mangelsdorf I, Wolterbeek AP, Kroese ED, Van Vugt-Lussenburg BM. (2015) A high throughput screening system for predicting chemically-induced endocrine disruption and sex organ deformities. Reprod. Toxicol. 55, 95-103
Ramos, M., Burgos, N., Barnard, A., Evans, G., Preece, J., Graz, M., Caroline Ruthes, A., Jiménez-Quero, A., Martínez-Abad, A., Vilaplana, F., Pham Ngoc, L., Brouwer, A., van der Burg, B., del Carmen Garrigós, M., Jiménez, A., (2019) Agaricus bisporus and its by-products as a source of valuable extracts and bioactive compounds, Food Chemistry 292, 176-187
Pham Ngoc L, Man HY, Besselink H, Dang Thi Cam H, Abraham Brouwer A, and Van der Burg, B. (2019) Identification of PPAR-activating compounds in herbal and edible plants and fungi from Vietnam using a comprehensive panel of PPAR reporter gene assays. Industrial Crops and Products 129, 195-200.
Pham Ngoc L, Helmus R, Ehlerse AW, Swart K, Besselink H, De Rijke E, Dang Thi Cam H, Brouwer A, Van der Burg B. (2021) Effect-directed analysis and chemical identification of agonists of peroxisome proliferator-activated receptors in white button mushroom. Food & Function 12, 133-143
Garrison PM, Tullis K, Aarts JM, Brouwer A, Giesy JP, Denison MS (1996) Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol. 30:194-203.
Van Vugt-Lussenburg, B., Van der Burg, B., Besselink, H., Brouwer, A. (2013) DR CALUX®, A high-throughput screening assay for the detection of dioxin and dioxin-like compounds in food and feed. In “High throughput screening methods in toxicity testing” (P. Steinberg, ed). John Wiley and Sons, Inc. New York. ISBN 9781118065631. Pp 553-546.
Budin C, Petrlik J, Behnisch P, Besselink H, Van der Burg B, Brouwer A. (2020) Detection of high PBDD/Fs levels in children’s toys and consumer goods using HR-GCMS and the cell-based DR CALUX® reporter gene assay. Chemosphere 251, 126579
Letcher, R.J., Lemmen, J.G., Van der Burg, B., Brouwer, A., Bergman A., Giesy, J.P., Van den Berg, M. (2002) In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene on 17β-estradiol-induced gene expression in several bioassay systems. Tox. Sciences. 69, 362-372.
Nyffeler J, Chovancova P, Dolde X, Holzer AK, Purvanov V, Kindinger I, Kerins A, Higton D, Silvester S, Van Vugt-Lussenburg B, Glaab E, Van der Burg B, Maclennan R, Legler DF, Leist M. (2018) A structure‐activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins. Arch Toxicol. 92:1225-1247
Pieterse B, Felzel E, Winter R, van der Burg B, Brouwer A (2013) PAH-CALUX, an optimized bioassay for carcinogenic hazard identification of polycyclic aromatic hydrocarbons (PAHs) as individual compounds and in complex mixtures. Environ Sci Technol, 47, 11651-11659.
Gauggel-Lewandowski, S, Heussner, A H., Steinberg, P, van der Burg, B, and Dietrich, D.R. (2013) Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro. Chem Biol Interact. 206,411-22
Talia C, Budin C, Panagiotis F, van der Burg B, Connolly L, Fowler PA. (2021) Disruption of Estrogenic and Androgenic Bioactivities in Human Fetuses Exposed to Maternal Smoking. J Endocr Soc. 5(Suppl 1):A496.
Collet B, Besselink H, Felzel E, Desalegn A, Naderman M, Niamut F, Schmid M, Swart K, Eggesbø M, Van der Burg B, Brouwer A. Possible role of Per- and polyfluoroalkylated substances (PFAS) in the thyroid-related endocrine activity observed in breast milk samples from the Norwegian HUMIS cohort, submitted.
Behnisch P,Besselink H, Weber R, Willand W, Huang J, Brouwer A.(2021) Developing potency factors for thyroid hormone disruption by PFASs using TTR-TRβ CALUX® bioassay and assessment of PFASs mixtures in technical products. Environment International 157, 106791
Sonneveld, E., Jansen, H.J., Riteco, J.A.C., Brouwer, A., Van der Burg, B. (2005) Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid responsive bioassays. Toxicol. Sci., 83, 136-48.
Houtman, C.J., Sterk, S.S., Van de Heijning, M.P., Brouwer, A., Stephany, R.W., Van der Burg, B., Sonneveld, E. (2009) Detection of anabolic androgenic steroid abuse in doping control using in vitro reporter gene bioassays. Analytica Chimica Acta 637,247-58.
Lanišnik Rižner, T., Brožič, P., Doucette, C., Turek-Etienne, T., Müller-Vieira, U., Sonneveld, E., Van der Burg, B., Böcker, C., and Husen B. (2011) Selectivity and potency of the retroprogesterone dydrogesterone in vitro. Steroids 76(6), 607-15.
Legler, J., Dennekamp, M., Vethaak, A.D., Brouwer, A., Koeman, J.H., Van der Burg, B., and Murk. A.J. (2002). Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays. Sci. Tot. Environ. 293, 69-83.
Murk AJ, Legler J, van Lipzig MM, Meerman JH, Belfroid AC, Spenkelink A, van der Burg B, Rijs GB, Vethaak D. (2002) Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays. Environ Toxicol Chem. 21, 16-23.
Pawlowski S, Ternes T, Bonerz M, Kluczka T, Van Der Burg B, Nau H, Erdinger L, Braunbeck T. (2003) Combined in Situ and in Vitro Assessment of the Estrogenic Activity of Sewage and Surface Water Samples. Tox. Sciences 75, 57-65.
Sonneveld, E., Jansen, H.J., Riteco, J.A.C., Brouwer, A., Van der Burg, B. (2005) Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid responsive bioassays. Toxicol. Sci., 83, 136-48.
Van der Burg, B., Van der Linden, S.C., Man, H.Y., Winter, R., Jonker, L., Van Vugt-Lussenburg, B., Brouwer, A. (2013) A panel of quantitative CALUX® reporter gene assays for reliable high throughput toxicity screening of chemicals and complex mixtures. In “High throughput screening methods in toxicity testing” (P. Steinberg, ed). John Wiley and Sons, Inc. New York. ISBN 9781118065631 pp. 519-532
Van der Linden, SC, von Bergh A, Van Vugt-Lussenburg B, Jonker L, Brouwer A, Teunis M, Krul C and Van der Burg B. (2014) Development of a panel of high throughput reporter gene assays to detect genotoxicity and oxidative stress, Mutation Res.760,23-32.
Van Vugt-Lussenburg, B., Van der Burg, B., Besselink, H., Brouwer, A. (2013) DR CALUX®, A high-throughput screening assay for the detection of dioxin and dioxin-like compounds in food and feed. In “High throughput screening methods in toxicity testing” (P. Steinberg, ed). John Wiley and Sons, Inc. New York. ISBN 9781118065631. Pp 553-546.
Budin C, Petrlik J, Behnisch P, Besselink H, Van der Burg B, Brouwer A. (2020) Detection of high PBDD/Fs levels in children’s toys and consumer goods using HR-GCMS and the cell-based DR CALUX® reporter gene assay. Chemosphere 251, 126579
Rosenmai AK, Taxvig C, Svingen T, Trier X, van Vugt-Lussenburg BM, Pedersen M, Lesné L, Jégou B, Vinggaard AM. Fluorinated alkyl substances and technical mixtures used in food paper-packaging exhibit endocrine-related activity in vitro. Andrology. 2016 Jul;4(4):662-72. doi: 10.1111/andr.12190. Epub 2016 May 6. PMID: 27152447.
Legler, J., Dennekamp, M., Vethaak, A.D., Brouwer, A., Koeman, J.H., Van der Burg, B., and Murk. A.J. (2002). Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays. Sci. Tot. Environ. 293, 69-83.
Van der Linden, S., Heringa, M.B., Man, H.Y., Sonneveld, E., Puijker, L., Brouwer, A., Van der Burg, B. (2008) Detection of multiple hormonal activities in waste water effluents and surface water, using a panel of steroid receptor CALUX bioassays, Environmental Science and Technology 42, 5814-20.
Schriks M, Van der Linden SC, Stoks PMG, Van der Burg B, Puijker L, De Voogt P, Heringa M. (2013) Occurence of glucocorticogenic activity in various surface waters in The Netherlands. Chemosphere. 93(2),450-454
Suzuki G, Tue NM, van der Linden S, Brouwer A, van der Burg B, Lamoree M, van Velzen M, Someya M, Takahashi S, Isobe T, Tajima Y, Yamada T, Takigami H, Tanabe S (2011) Identification of major dioxin-like compounds and androgen receptor antagonist in Acid-treated tissue extracts of high trophic-level animals. Env Science & Technol., 45,10203-11
Brussaard C, Peperzak L, Beggah S, Wick LY, Wuerz B, Weber J, Arey JS, Van der Burg B, Jonas A, Huisman J, Van der Meer JR. (2016) Immediate Ecotoxicological Effects of Short-Lived Marine Oil Spills Detected by Rapid on-site Biological Assays on Marine Biota. Nature Communications 7,11206-11216
Drakvik E, Altenburger R, Aoki Y, Backhaus T, Bahadori T, Barouki R, Brack W, Cronin MTD, Demeneix B, Hougaard Bennekou S, van Klaveren J, Kneuer C, Kolossa-Gehring M, Lebret E, Posthuma L, Reiber L, Rider C, Rüegg J, Testa G, van der Burg B, van der Voet H, Warhurst AM, van de Water B, Yamazaki K, Öberg M, Bergman Å. (2019) Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment. Environ Int. 134:105267.
Van der Burg, B., Schreurs, R., Van der Linden, S., Seinen, W., Brouwer, A., Sonneveld, E. (2008) Endocrine effects of polycyclic musks, do we smell a rat?”. Int. J. Andrology, 31,188-93.
ENV/JM/MONO(2020)16. Case Study on use of an Integrated Approach to Testing and Assessment (IATA) and New Approach Methods to Inform a Theoretical Read-Across for Dermal Exposure to Propylparaben from Cosmetics.
Dent MP, Li H, Carmichael PL, Martin FL. Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data. Toxicol Sci. 2019;167(2):375-384. doi:10.1093/toxsci/kfy245
Besselink H, Brouwer A, Van der Burg B. (2017) Validation and regulatory acceptance of bio-based approaches to assure feedstock, water & product quality in a bio-based economy. Industrial Crops and Products 106, 138-145.
Franciolus D, Van Vugt-Lussenburg B, Niamut F, Man HY, Van der Burg B, Kroese D, Buist H, Meima M, Byrne F, Sherwood J, van Es D. Designing safe bio-based solvents: introducing conformationally induced physical properties using the isohexide scaffold, submitted.
Sherwood J, Buist HE, Van der Burg B, Byrne FP, Camp JE, Farmer TJ, E. Kroese ED, Meima MY, Méndez Sevillano D, Puente A, Van Vugt-Lussenburg BMA, Clark JH (2020) Designing Renewable, High-Performance Solvents with Improved Toxicity Profiles. Aldrichimica ACTA VOL. 53, 57-63
Vafeiadi M, Agramunt S, Papadopoulou E, Besselink H, Mathianaki K, Karakosta P, Spanaki A, Koutis A, Chatzi L, Vrijheid M, Kogevinas M.(2013) In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants. Environ Health Perspect ;12:125-30.
Collet B, Desalegn A, Swart K, Naderman M, Iszatt N, Stigum H, Jensen T, Brouwer A, Eggesbø M, Van der Burg B. Anti-Androgenic Compounds in Breast Milk and Cryptorchidism Among Norwegian Boys in the HUMIS Birth Cohort, Science of the Total Environment, in press
Inda MA, Blok EJ, Kuppen PJK, Charehbili A, den Biezen-Timmermans EC, van Brussel A, Fruytier SE, Meershoek-Klein Kranenbarg E, Kloet SL, van der Burg B, Martens JWM, Sims AH, Turnbull AK, Dixon JM, Verhaegh W, Kroep JR, van de Velde CJH, van de Stolpe A. (2019) Estrogen Receptor pathway activity score to predict clinical response or resistance to neo-adjuvant endocrine therapy in primary breast cancer. Mol Cancer Ther. 19, 680-689.
Young AS, Zoeller T, Hauser R, James-Todd T, Coull BA, Behnisch PA, Brouwer A, Zhu H, Kannan K, Allen JG. Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays. Environ Health Perspect. 2021 Apr;129(4):47010
Krebs A, van Vugt-Lussenburg BMA, Waldmann T, Albrecht W, Boei J, Ter Braak B, Brajnik M, Braunbeck T, Brecklinghaus T, Busquet F, Dinnyes A, Dokler J, Dolde X, Exner TE, Fisher C, Fluri D, Forsby A, Hengstler JG, Holzer AK, Janstova Z, Jennings P, Kisitu J, Kobolak J, Kumar M, Limonciel A, Lundqvist J, Mihalik B, Moritz W, Pallocca G, Ulloa APC, Pastor M, Rovida C, Sarkans U, Schimming JP, Schmidt BZ, Stöber R, Strassfeld T, van de Water B, Wilmes A, van der Burg B, Verfaillie CM, von Hellfeld R, Vrieling H, Vrijenhoek NG, Leist M. (2020). The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods. Arch Toxicol 94, 2435–2461
Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG. (2017) Adverse outcome pathways: opportunities, limitations and open questions. Arch. Toxcol. 91:3477-3505.
Becker R, Ankley G, Edwards S, Kennedy S, Linkov I, Meek B, Sachana M, Segner H, Van Der Burg B, Villeneuve D, Watanabe H, Barton-Maclaren TS. (2015) Increasing Scientific Confidence in Adverse Outcome Pathways, Application of Tailored Bradford Hill Considerations for Evaluating Weight of Evidence. Regul Toxicol Pharmacol. 72, 514-5
Lanišnik Rižner, T., Brožič, P., Doucette, C., Turek-Etienne, T., Müller-Vieira, U., Sonneveld, E., Van der Burg, B., Böcker, C., and Husen B. (2011) Selectivity and potency of the retroprogesterone dydrogesterone in vitro. Steroids 76(6), 607-15.
Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG. (2017) Adverse outcome pathways: opportunities, limitations and open questions. Arch. Toxcol. 91:3477-3505.
Van Vugt-Lussenburg B, Van Es D, Naderman M, le Notre J, van der Klis F, Brouwer A, Van der Burg B. (2020) Endocrine activities of phthalate alternatives; assessing the safety profile of furan dicarboxylic acid esters using a panel of human cell based reporter gene assays. Green Chemistry 22, 1873-1883
Besselink H, Brouwer A, Van der Burg B. (2017) Validation and regulatory acceptance of bio-based approaches to assure feedstock, water & product quality in a bio-based economy. Industrial Crops and Products 106, 138-145.
Collet B, Simon E, Van der Linden S, El Abdellaoui N, Naderman M, Man HY, Middelhof I, Van der Burg B, Besselink H, Brouwer A. (2019) Validation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities. Reproductive Toxicol., 18, 30554-30559
Milcamps A, Liska R, Langezaal I, Casey W, Dent M, Odum J. Reliability of the AR-CALUX® in Vitro method used to detect chemicals with (anti)androgen activity: results of an international ring trial. Toxicol Sci. 2021 Jun 24:kfab078. doi: 10.1093/toxsci/kfab078. Epub ahead of print. PMID: 34165557.
Commission Regulation (EU) No 252/2012 of 21 March 2012 laying down methods of sampling and analysis for the official control of levels of dioxins, dioxin- like PCBs and non-dioxin-like PCBs in certain foodstuffs and repealing Regulation (EC) No 1883/2006
Commission Regulation (EU) No 278/2012 of 28 March 2012 amending Regulation (EC) No 152/2009 as regards the determination of the levels of dioxins and polychlorinated biphenyls.
ISO 19040-3 Water quality — Determination of the estrogenic potential of water and waste water — Part 3: In vitro human cell-based reporter gene assay.
OECD (2020), Test No. 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris.
OECD (2021), Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris.
US-EPA. SW-846 Test Method 4435: Screening For Dioxin-Like Chemical Activity In Soils And Sediments Using The Calux Bioassay And Toxic Equivalents (TEQs) Determinations.
Pham Ngoc L, Helmus R, Ehlerse AW, Swart K, Besselink H, De Rijke E, Dang Thi Cam H, Brouwer A, Van der Burg B. (2021) Effect-directed analysis and chemical identification of agonists of peroxisome proliferator-activated receptors in white button mushroom. Food & Function 12, 133-143
Collet, B, van Vugt-Lussenburg B, Swart K, Helmus R, Naderman M, de Rijke E, Eggesbø M, Brouwer A, van der Burg B. (2020) Antagonistic activity towards the androgen receptor independent from natural sex hormones in human milk samples from the Norwegian HUMIS cohort. Environment Int. 14: 143
Klingelhofer I, Pham Ngoc, L, Van der Burg B, Morlock GE. A bioimaging system combining human cultured reporter cells and planar chromatography to identify novel bioactive molecules. Analytical Chemistry, in press